Pregnancy Exams: Diagnostic pregnancy tests dependant on immunological reactions among HCG and anti-HCG may possibly lead to Phony-detrimental or Wrong-optimistic interpretations.
Promethazine with Codeine Oral Answer is not proposed for use in pregnant Girls [see Use in Unique Populations (8.1)]. Extended use of Promethazine with Codeine Oral Remedy through pregnancy may end up in neonatal opioid withdrawal syndrome, which can be lifetime-threatening Otherwise regarded and addressed, and necessitates administration according to protocols formulated by neonatology gurus.
Use caution When it comes to the usage of Promethazine with Codeine Oral Option in clients 65 years of age or older. Elderly patients may have elevated sensitivity to codeine; bigger frequency of lowered hepatic, renal, or cardiac function; or concomitant disorder or other drug therapy [see Warnings and Precautions ( 5.six) ]. Respiratory melancholy may be the Main chance for elderly individuals handled with opioids, which includes Promethazine with Codeine Oral Option. Respiratory melancholy has happened immediately after significant Original doses of opioids have been administered to clients who weren't opioid-tolerant or when opioids were being co-administered with other brokers that depress respiration [see Warnings and Precautions ( 5.
This medication may perhaps interfere with specified lab exams (like some pregnancy assessments, blood sugar checks, amylase/lipase amounts), possibly leading to Wrong test success. Be certain lab personnel and all your Medical professionals know you use this drug.
This medication can dry up and thicken mucus as part of your lungs, rendering it more challenging to breathe and crystal clear your lungs. To aid avert this outcome, drink plenty of fluids unless usually directed by your health practitioner.
Discontinuation of the concomitantly utilised cytochrome P450 2D6 inhibitor may well end in a decrease in codeine plasma concentration and a rise in Lively metabolite morphine plasma concentration which could increase or extend adverse reactions and could bring about probably lethal respiratory depression.
This solution may well have inactive components, which may cause allergic reactions or other challenges. Speak with your pharmacist For additional details.
Carcinogenicity scientific studies were being performed with codeine. Two-12 months experiments in F344/N rats and B6C3F1 mice had been carried out to evaluate the carcinogenic potential of codeine. No evidence of tumorigenicity was observed in male and feminine rats at codeine dietary doses as many as 70 and 80 mg/kg/working day (close to comparable to 15 and twenty situations, the MRHD with a mg/m2 basis, respectively).
Asthma Together with other website Respiratory Conditions: Narcotic analgesics or cough suppressants, including codeine, should not be used in asthmatic sufferers (see CONTRAINDICATIONS). Nor need to they be Utilized in acute febrile health issues linked with effective cough or in Continual respiratory ailment wherever interference with power to distinct the tracheobronchial tree of secretions would have a deleterious effect on the patient’s respiratory perform.
Absorption Codeine is absorbed within the gastrointestinal tract with highest plasma focus taking place sixty minutes publish administration. The presence of the superior-Body fat, higher-calorie food didn't noticeably influence the PK of codeine.
Ahead of using this medication, inform your medical professional or pharmacist When you are allergic to any of its ingredients; or to opioid pain relievers (such as morphine); or if you have another allergies.
To reduce the risk of dizziness and lightheadedness, get up slowly and gradually when climbing from a sitting or lying place.
Impaired secretion from sweat glands next poisonous doses of medications with anticholinergic Unwanted effects may predispose to hyperthermia.
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